to death. In a number of cases, it appears possible that the cerebrovascular events were primary, the 5-HT1 agonists having been administered in the incorrect belief that the symptoms experienced were a consequence of migraine when they were not. Sumatriptan presumably exerts its therapeutic effects in the treatment of migraine headache through agonist effects at the 5-HT1B/1D receptors on intracranial blood vessels and sensory nerves of the trigeminal system, which result in cranial vessel constriction and inhibition of pro-inflammatory neuropeptide release. The Alsuma Auto-Injector Figure 3 When the Blue Safety Release is in place, Alsuma Is locked and will not inject. The highest oral and intravenous no-effect doses for developmental toxicity in rabbits were 15 and.75 mg/kg/day, respectively. Read the Instructions for Use that come with Alsuma. Keep out of the reach of children. Cerebrovascular Events Cerebral hemorrhage, subarachnoid hemorrhage, and stroke have occurred in patients treated with 5-HT1 agonists, and some have resulted in fatalities. Animal Toxicology and/or Pharmacology Corneal Opacities: Dogs receiving oral sumatriptan developed corneal opacities and defects in the corneal epithelium. Risk of Myocardial Ischemia and/or Infarction, Prinzmetal's Angina, Other Vasospasm-Related Events, Arrhythmias, and Cerebrovascular Events Inform patients that Alsuma may cause serious cardiovascular side effects such as myocardial infarction or stroke.
The maximum recommended dose that may be given in 24 hours is two doses of Alsuma separated by at least 1 hour. Following a 6-mg subcutaneous injection into the deltoid area of the arm in 9 males ( mean age: 33 years, mean weight: 77 kg) the volume of distribution central compartment of sumatriptan was 50 8 liters and the distribution half-life was 15 2 minutes. (see Figure 3 ) Figure 4 When the Blue Safety Release is taken off, Alsuma is unlocked and ready to use. If you are not sure if you have these types of migraines, ask your healthcare provider. How should I store Alsuma? (see Figure 14 ) Figure 14 Hold the Alsuma Auto-Injector in the middle.
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